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The causes of ageing are uncertain; current theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA oxidation) may cause biological systems to fail, or to the programmed ageing concept, whereby internal processes (such as DNA methylation) may cause ageing.Programmed ageing should not be confused with programmed cell death (apoptosis).Reaction time, for example, may slow with age, while knowledge of world events and wisdom may expand.Ageing is among the greatest known risk factors for most human diseases: of the roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes.fall into two main categories, programmed and damage-related.Programmed factors follow a biological timetable, perhaps one that might be a continuation of the one that regulates childhood growth and development.
However, in a comparative analysis in 2014, the Wisconsin researchers found that the allegedly non-starved NIA control monkeys in fact are moderately underweight when compared with other monkey populations, and argued this was due to the NIA's apportioned feeding protocol in contrast to Wisconsin's truly unrestricted ad libitum feeding protocol.
Once these factors are accounted for, the optimal body weight above age 65 corresponds to a leaner body mass index of 23 to 27.
Alternatively, the benefits of dietary restriction can also be found by changing the macro nutrient profile to reduce protein intake without any changes to calorie level, resulting in similar increases in longevity.
Ageing or aging (see spelling differences) is the process of becoming older.
The term refers especially to human beings, many animals, and fungi, whereas for example bacteria, perennial plants and some simple animals are potentially immortal.
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Some of the targeted genes have homologues across species and in some cases have been associated with human longevity.